IPHD Lab
Immune Profiling in Human Diseases Laboratory
Understanding immune mechanisms in human diseases through cutting-edge epigenomic approaches and collaborative research excellence.
Understanding immune mechanisms in human diseases through cutting-edge epigenomic approaches and collaborative research excellence.
Understanding immune mechanisms in human diseases
The Immune Profiling in Human Diseases (IPHD) Laboratory, led by Dr. Kyuho Kang, focuses on understanding the complex interplay between immune responses and various human diseases. Our research applies cutting-edge epigenomic approaches to investigate immune cell functions in the context of cancer and chronic inflammatory conditions.
We utilize advanced genomic and epigenomic technologies to profile immune cells and understand how their functions are dysregulated in disease states. Our work has significant implications for the development of novel therapeutic strategies for cancer and inflammatory disorders.
Located at Chungbuk National University's Department of Biology, our team collaborates with clinicians and researchers globally to translate fundamental discoveries into clinical applications.
Single-cell genomics, epigenomics, and multiomics approaches
International partnerships for translational research
Translating discoveries into therapeutic applications
Our key areas of investigation
We apply cutting-edge techniques including ChIP-seq, ATAC-seq, CUT&Tag, RNA-seq, and single-cell multi-omics to map the epigenetic landscapes of immune cells in health and disease.
We investigate the epigenetic and transcriptional regulation of macrophage activation and polarization in response to cytokines and environmental signals, with special focus on interferon and JAK-STAT signaling pathways.
Our research explores how tumor-associated macrophages and other immune cells are regulated in the cancer microenvironment, focusing on epigenetic reprogramming that drives cancer progression.
We study the underlying mechanisms of chronic inflammatory conditions, including rheumatoid arthritis and chronic rhinosinusitis, to identify novel therapeutic targets.
Our lab works on identifying and validating biomarkers for disease diagnosis, prognosis, and treatment response, with patents for bladder cancer prognostic markers.
We develop and apply bioinformatic approaches to integrate multi-omics data for uncovering novel biological insights and potential therapeutic targets.
Associate Professor
Department of Biology, College of Natural Sciences
Chungbuk National University
Selected recent publications from our laboratory
Authors: Jaewoo Park, Jung Yeon Jang, Jeong Heon Kim, Se Eun Yi, Yeong Ju Lee, Myeong Sang Yu, Yoo-Sam Chung, Yong Ju Jang, Ji Heui Kim, and Kyuho Kang
Experimental & Molecular Medicine (2025)
Authors: Geunho Kwon, Yebin Park, Keunsoo Kang, Kyung-Hyun Park-Min, and Kyuho Kang
iScience (2025)
Authors: Jaehyun Lee, Chaelin You, Geunho Kwon, Junho Noh, Kyubin Lee, Kyunghwan Kim, Keunsoo Kang, Kyuho Kang
Cell Death & Disease (2024)
Authors: Kyuho Kang, Mahesh Bachu, Sung Ho Park, Keunsoo Kang, Seyeon Bae, Kyung-Hyun Park-Min and Lionel B. Ivashkiv (Co-corresponding author)
Nature Communications (2019) - Cited by 116
Authors: Kyuho Kang, Sung Ho Park, Janice Chen, Yu Qiao, Eugenia Giannopoulou, Karen Berg, Adedayo Hanidu, Jun Li, Gerald Nabozny, Keunsoo Kang, Kyung-Hyun Park-Min and Lionel B. Ivashkiv
Immunity (2017) - Cited by 202
Meet our dedicated research team
Principal Investigator
Associate Professor
Ph.D. Student
Cancer Epigenomics
Ph.D. Student
Macrophage Epigenomics
Ph.D. Student
Inflammatory Disease Research
Ph.D. Student
Cancer Biology
Ph.D. Student
Cancer Epigenomics
Ph.D. Student
Cytokine Signaling
Undergraduate Student
Research Assistant
Get in touch with our research team
Institution
Department of Biology, College of Natural Sciences
Chungbuk National University
ORCID
0000-0003-3448-5336ResearchGate
IPHD Lab ProfileWe welcome motivated students and researchers interested in immunology, epigenetics, and computational biology. Please contact us to discuss potential opportunities.